Our peer-reviewed publication on novel linker molecules for our proprietary P5-conjugation platform to develop ADCs with higher stability is now available openly at the European Journal of Organic Chemistry.
The publication gives further insights in how we leverage linker molecules that carry two phosphonamidate electrophiles to develop protein-protein constructs and homogenous ADCs. By using a third chemoselective modification we were also able to attach a fluorophore to the ADC, enabling the direct visualization of cellular ADC uptake.
The full publication can be found here.