Harnessing the power of ADCs with our two proprietary technology platforms
Tubulis has developed a dual platform approach for the discovery and development of a new generation of versatile and customizable antibody-drug conjugates (ADCs). At the heart of both proprietary platforms are completely new conjugation technologies, that allow us to overcome the main limitations of ADC technologies to date:
lack of stability of ADCs
off-target payload toxicity
systemic side effects
Depending on the indication and the needs for both the chemical component and the antibody, we can leverage the right platform to create uniquely matched ADCs that enable us to provide drug candidates that can make a difference in a variety of cancer indications and beyond.
P5 conjugation platform
Fine-tuning the chemical latch for ADCs
Our P5 conjugation technology uses a cysteine-selective conjugation mechanism. This allows to rapidly generate ultra-stable ADCs with unprecedented linker stability and chemical flexibility, providing us with the opportunity to screen and characterize lead compounds.
Rapid lead identification of any mAb/toxin combination
Novel cysteine-selective chemistry
Unique stability and selectivity
No mAb engineering required
The Tub-tag® platform
Remodeling the ADC microenvironment
Our second technology, the Tub-tag® platform was inspired by microtubule biology and adds a significant amount of stability to the ADC product candidates by modulating the antibody to provide a highly beneficial microenvironment for the payload. Moreover, the human-derived nature of the Tub-tag® lowers the risk of the ADC causing unwanted immune reactions.
Turning screening hits into transformative ADC
Homogeneous ADCs with improved therapeutic index
Defined drug loads with high DAR flexibility
Tub-tag® provides highly beneficial microenvironment for site-specific payload conjugation
Both technology platforms are covered through our extensive IP portfolio.
Selected Publications for a deeper dive:
M.A. Kasper, M. Glanz., A. Stengl, M. Penkert, S. Klenk, T. Sauer, D. Schumacher, J. Helma, M.C. Cardoso, H. Leonhardt, C.P. Hackenberger, Angew Chem Int Ed Engl. 2019.
M.A. Kasper, A. Stengl, P. Ochtrop, M. Gerlach, T. Stoschek, D. Schumacher, J. Helma, M. Penkert, E. Krause, H. Leonhardt, C.P. Hackenberger, Angew Chem Int Ed Engl. 2019.
Schumacher, J. Helma, F. A. Mann, G. Pichler, F. Natale, E. Krause, M. C. Cardoso, C. P. Hackenberger, H. Leonhardt, Angew Chem Int Ed Engl. 2015.
D. Schumacher, O. Lemke, J. Helma, L. Gerszonowicz, V. Waller, T. Stoschek, P. M. Durkin, N. Budisa, H. Leonhardt, B. Keller, C. P. Hackenberger, Chem Sci. 2017.