Publications

For a Deeper Dive

TUB-040

TUB-040, a homogenous and hydrophilic NaPi2b-targeting ADC with stably linked exatecan, exhibits long-lasting anti-tumor activity and a well-tolerated safety profile.

Molecular Cancer Therapeutics
2025
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P5 Conjugation Platform

Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates.

Molecular Cancer Therapeutics
2024
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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile. 

Chemical Science
2023
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Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.

Angewandte Chemie
2019
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Ethynyl-phosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.

Angewandte Chemie
2019
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N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates.

ChemBioChem
2019
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Tub-tag® Conjugation Platform

TUB-010, a novel anti-CD30 antibody-drug conjugate based on Tub-tag technology, widens the therapeutic window by reducing toxicity while maintaining high efficacy.

Molecular Cancer Therapeutics
2025
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Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.

Chemical Science
2017
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Current Status: Site-Specific Antibody Drug Conjugates.

Journal of Clinical Immunology
2000
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Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

Angewandte Chemie
2015
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Academic Collaborations

Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols.

J. Am. Chem. Soc.
2025
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Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates.

Leukemia
2025
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Targeting FLT3 By New-Generation Antibody-Drug-Conjugate In Combination With KinaseInhibitors For Treatment Of AML.

Blood
2022
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Bis-ethynyl-phosphonamidatesas an Modular Conjugation Platform to Generate Multifunctional Protein- and Antibody-Drug-Conjugates.

European Journal of Organic Chemistry
2022
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The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols.

Chemical Science
2021
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Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization.

Chemical Science
2019
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